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DFG Collaborative Research Centre 1470

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Charité – Universitätsmedizin Berlin

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Projects

Get an impression of the subprojects of the Collaborative Research Center 1470

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Subprojects area A: Disease Mechanisms

A01 - Heinzel/Paolo Ventricular compartmentalization and functional reserve in cardiomyocytes in HFpEF

A05 - Dechend/Forslund Role of sex hormones on microbiome, immunity, and coronary microvascular dysfunction and rarefication in experimental HFpEF

A09 - Kintscher/Sigrist Lipid-mediated mitochondrial dysfunction in HFpEF during obesity

A02 - Schiattarella Lipid-based control of the unfolded protein response in HFpEF

A06 - Sawamiphak/Müller Immune regulation of vascular rarefaction and diastolic myocardial remodeling

A10 - Wilck Connecting the gut microbiota to the cardiorenal axis in HFpEF

A03 - Gerhardt/Landmesser Linking metabolism, mechanotransduction and endothelial dysfunction in HFpEF

A07 - van Linthout Sterile inflammation and innate immunity in HFpEF

A04 - Kübler/Grune Cardio-pulmonary interaction in HFpEF

A08 - Beling/Berndt Metabolic reprogramming steered by ISGylation in HFpEF

Subprojects area B: Phenomics, Stratification, and Target Development

B01 - Falk/Hohendanner/Zhang Atrial mechanical and secretory function in human HFpEF

B05 - Edelmann/Mertins Molecular plasticity of HFpEF

B02 - Tschöpe Myocardial immune cell activation and fibrosis

B06 - Kelle/Hennemuth Imaging structure/function relations in HFpEF – from pathomechanisms to artificial intelligence-based classification

B03 - Hübner Hypertension and metabolic stress associated changes in cardiac cell populations

B07 - Thum Mechanisms, therapeutics and diagnostic potential of circular RNAs in HFpEF

B04 - Gotthardt A systems and translational approach to titin dynamics in HFpEF

Subprojects area Z: Central Projects and ICT Infrastructure

Z01 - Heinzel/Alonga/Gotthardt Animal models and human Engineered Heart Tissue

Z02 - Edelmann/Grittner/Tschöpe Multilevel human HFpEF phenotyping

Z03 - Eils/Kühne Phenomapping and systems modelling